OSTEOCHONDRAL-ON-CHIP is a microphysiological system designed to recreate the interface between cartilage and subchondral bone. It integrates chondrocytes and osteoblasts (or stem-cell-derived counterparts) within a structured microenvironment that mimics the biochemical and mechanical gradients of the osteochondral unit.

This platform enables the study of tissue crosstalk and degeneration processes at the bone–cartilage interface.