OUR RESEARCH
AI-TWIN specializes in creating organ-on-chip models that replicate the intricate 3D structure, of all the relevant tissues within a system starting from the design and fabrication of the microfluidic platforms, to setting the SOPs for primary cell culture starting from patient’s biopsy. These models encompass blood vessels and immune components where applicable.
AI-TWIN leads the way in 3D tissue/organ on-chip innovation, accurately replicating the intricate complexity of various pathophysiological conditions.
These platforms advance preclinical research across a spectrum of fields, including but not limited to autoimmune diseases and neuroscience. They play a pivotal role in advancing animal-free drug testing methodologies.
WE THRIVE
TO ACHIEVE
Our mission is to develop Organ-On-Chip platforms to generate vast amounts of high-quality biological data analyzed through multi-omic approaches and advanced imaging techniques, in order to develop the next-generation 3D models that are positioned to set a new benchmark in drug development and potentially replace animal experimentation.
To provide the next-generation in vitro models, biological twins, that facilitate the rapid acquisition of large amount of relevant human data, in order to increase knowledge on complex mechanisms generating a digital twin, allowing to reduce clinical failure and empowering the pharmaceutical industry to develop effective drugs more more rapidly and cost-effectively.
OUR PRODUCTS
AI-TWIN OoCs enable reproduction of a biological twin of the patient, starting from a patient biopsy, and use them to identify the most effective therapy for that patient in a fast, safe and ethical way.
Our OoC are integrated with imaging systems and sensors that read, in real time, chemical and physical variations of the cells of the newly generated tissue in culture. Obtained data are processed with artificial intelligence techniques, creating a digital twin, the synchronous virtual representation of the state of the cells.
These digital twins offer a personalized computational model that can assist in drug development, treatment optimization, and eventually lead to precision medicine tailored to individual patients
UNIQUE CHARACTERISTICS
Integrated mechanical actuator that simulate compressive, hydrostatic, and shear stresses
Completely autologous system
Implementation of the immune system in the device, combined with the vascular compartment
APPLICATIONS
- Academic research in the field of biomedicine – translational research aimed at identifying new therapeutic biomarkers
- Clinical practice – more effective therapies, paediatric medicine
- Pharmaceutical sector – drug discovery, drug repurposing
- Environmental industry – evaluation of the toxicity of substances
- Cosmetic industry
SCIENTIFIC COLLABORATIONS
FLAMIN-GO
From pathobioLogy to synoviA on chip: driving rheuMatoId arthritis to the precisioN medicine Goal
Funded by: European Union’s Horizon 2020 research and innovation programme
TWINs4RA
Synovium’s biological and digiTal twin on a chip vascularized and analyzed via Webcam in the transition towards the P4 medicine to treat Rheumatoid Arthritis – call for proposals for academic Proof of Concept, PoC, within the North West Digital and Sustainable, NODES, ecosystem, of the National Recovery and Resilience Plan, PNRR.
Funded by: Italian Ministry of University and Research
INNDIANA
Autologous synovia-on-chip: a sustainable preclinical model for drug discovery and clinical trials on chip for Rheumatoid arthritis – call for proposals for academic Proof of Concept, PoC, within the North West Digital and Sustainable, NODES, ecosystem, under SPOKE 5 – Industry of Health and Silver Economy, of the National Recovery and Resilience Plan, PNRR.
Funded by: Italian Ministry of University and Research
OUR RESEARCH
AI-TWIN specializes in creating organ-on-chip models that replicate the intricate 3D structure, of all the relevant tissues within a system starting from the design and fabrication of the microfluidic platforms, to setting the SOPs for primary cell culture starting from patient’s biopsy. These models encompass blood vessels and immune components where applicable.
AI-TWIN leads the way in 3D tissue/organ on-chip innovation, accurately replicating the intricate complexity of various pathophysiological conditions.
These platforms advance preclinical research across a spectrum of fields, including but not limited to autoimmune diseases and neuroscience. They play a pivotal role in advancing animal-free drug testing methodologies.
WE THRIVE
TO ACHIEVE
Our mission is to develop Organ-On-Chip platforms to generate vast amounts of high-quality biological data analyzed through multi-omic approaches and advanced imaging techniques, in order to develop the next-generation 3D models that are positioned to set a new benchmark in drug development and potentially replace animal experimentation.
To provide the next-generation in vitro models, biological twins, that facilitate the rapid acquisition of large amount of relevant human data, in order to increase knowledge on complex mechanisms generating a digital twin, allowing to reduce clinical failure and empowering the pharmaceutical industry to develop effective drugs more more rapidly and cost-effectively.
OUR PRODUCTS
AI-TWIN OoCs enable reproduction of a biological twin of the patient, starting from a patient biopsy, and use them to identify the most effective therapy for that patient in a fast, safe and ethical way.
Our OoC are integrated with imaging systems and sensors that read, in real time, chemical and physical variations of the cells of the newly generated tissue in culture. Obtained data are processed with artificial intelligence techniques, creating a digital twin, the synchronous virtual representation of the state of the cells.
These digital twins offer a personalized computational model that can assist in drug development, treatment optimization, and eventually lead to precision medicine tailored to individual patients
UNIQUE
CHARACTERISTICS
Integrated mechanical actuator that simulate compressive, hydrostatic, and shear stresses
Completely autologous system
Implementation of the immune system in the device, combined with the vascular compartment
APPLICATIONS
- Academic research in the field of biomedicine – translational research aimed at identifying new therapeutic biomarkers
- Clinical practice – more effective therapies, paediatric medicine
- Pharmaceutical sector – drug discovery, drug repurposing
- Environmental industry – evaluation of the toxicity of substances
- Cosmetic industry
SCIENTIFIC COLLABORATIONS
FLAMIN-GO
From pathobioLogy to synoviA on chip: driving rheuMatoId arthritis to the precisioN medicine Goal
Funded by: European Union’s Horizon 2020 research and innovation programme
TWINs4RA
Synovium’s biological and digiTal twin on a chip vascularized and analyzed via Webcam in the transition towards the P4 medicine to treat Rheumatoid Arthritis – call for proposals for academic Proof of Concept, PoC, within the North West Digital and Sustainable, NODES, ecosystem, of the National Recovery and Resilience Plan, PNRR.
Funded by: Italian Ministry of University and Research
INNDIANA
Autologous synovia-on-chip: a sustainable preclinical model for drug discovery and clinical trials on chip for Rheumatoid arthritis – call for proposals for academic Proof of Concept, PoC, within the North West Digital and Sustainable, NODES, ecosystem, under SPOKE 5 – Industry of Health and Silver Economy, of the National Recovery and Resilience Plan, PNRR.
Funded by: Italian Ministry of University and Research
Ai-Twin srl
Sede legale e operativa
C.so Trieste, 15/A – 28100 Novara (NO)
C.F./P.IVA 02722210032
SDI SUBM70N
USEFUL LINKS
WHERE TO FIND US